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Diclofenac-d4 contains four deuterium atoms on the benzene ring. It is intended for use as an internal standard for the quantification of diclofenac by GC- or LC-mass spectrometry. Diclofenac is a non-selective COX inhibitor.1,2,3 It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively.1,2 Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.3

1.Laneuville, O., Breuer, D.K., DeWitt, D.L., et al.Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugsJ. Pharmacol. Exp. Ther.271(2)927-934(1994) 2.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim Biophys. Acta.1209(1)130-139(1994) 3.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995)

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