化学性质:
规格 | 1 mg 5 mg 10 mg |
CAS | 2514-37-6 |
别名 | N/A |
化学名 | N/A |
分子式 | C15H13NOS |
分子量 | 255.3 |
溶解度 | DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 34.1 nM).1 It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.
1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(3)1261-1280(2020)
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标签:CAY10762
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