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Caerulein is an oligopeptide originally isolated from skin extracts of H. caerulea/L. caerulea. In vivo, caerulein increases the flow rate of gastric juices as well as pepsin and acid outputs in the gut of dogs, rats, and frogs. Caerulein (25-500 ng/kg) stimulates insulin secretion in a dose-dependent manner in anesthetized dogs. It is also used to induce pancreatitis in various animal models, as it increases autophagic vacuole formation and lysosomal enzyme activity leading to acinar cell necrosis when administered at a dose of 5 or 10 μg/kg per hour.

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