化学性质:
规格 | 5mg 10mg 50mg |
CAS | 112726-66-6 |
别名 |
|
化学名 | 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine |
分子式 | C19H25NS |
分子量 | 299.47 |
溶解度 | DMF: 5 mg/ml,Ethanol: 2 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Benocyclidine is an inhibitor of dopamine reuptake [1, 2].
Dopamine plays important roles in the brain and body. In the brain, dopamine functions as a neurotransmitter involved in reward-motivated behavior, motor control and controlling the release of various hormones. Dysfunctions of the dopamine system have been associated several important diseases including Parkinson's disease, attention deficit hyperactivity disorder, schizophrenia, and addiction [3]. Dopamine also functions in blood vessels, kidneys, pancreas, the digestive system, the immune system, and the blood vessels.
Benocyclidine (BTCP) was a derivative of phencyclidine (PCP) with a benzothiophenyl group instead of a phenyl ring. BTCP potently inhibited dopamine (DA) uptake with the IC50 of 7-8 nM. BTCP showed low affinity for the PCP receptor with the IC50 of 6 μM [1, 2]. In the striatum, BTCP binding was dose-dependently inhibited by unlabeled BTCP and nomifensine with the ID50 of 6.34 mg/kg and 11.06 mg/kg, respectively. BTCP bound to the dopamine uptake complex in the mouse brain in vivo [4].
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
联系人:高小姐
手 机:13585831301
Q Q:3004967995
座 机:021-59541103
传 真:021-60443211
地 址:上海市嘉定区澄浏公路52号中科院技术转移中心24号楼