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Bendiocarb is a broad-spectrum carbamate insecticide and an inhibitor of acetylcholinesterase (Ki = 111 nM for the human enzyme).1 It is active against several species, including second stage nymph German cockroaches (B. germanica; IC50 = <0.5 mg/ft2) and adult yellow fever mosquitoes (A. aegypti; IC50 = <0.03 mg/ft2).2 It is toxic to mammalian species with an oral LD50 value of 45 mg/kg for male rats and female mice, but it is metabolized and excreted rapidly and has a dermal LD50 of 800 mg/kg after a 24-hour exposure. Formulations containing bendiocarb have been used in the indoor control of insects, including for mosquitoes in areas with malaria transmission.

1.Verma, A., Wong, D.M., Islam, R., et al.3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiaeBioorg. Med. Chem.23(6)1321-1340(2015) 2.Brooker, P.J., Gates, P.S., Gillon, J., et al.Insecticidal activity of certain benzodioxolyl carbamatesPestic. Sci.3(6)735-744(1972)

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