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Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

Hemokinin 1 (mouse) (1nM-3μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80mM). Hemokinin 1 (mouse) (10nM-10μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1].

Hemokinin 1 (mouse) (0.01-100nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2nmol/kg (0.1-0.4nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1nmol/kg (0.07-0.2nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1].

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