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Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Research found that amyloid beta-protein circulates in human blood and in cerebrospinal fluid and is deposited into plaques found in the brains of patients with Alzheimer's disease (AD). The aggregation of the beta-amyloid protein into dense plaques on the exterior of brain cells results in destroys of the synapses and conduction of nerve impulses.

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