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Aclidinium Bromide is a long-acting antagonist of muscarinic (LAMAs) [1].

Aclidinium Bromide has been reported to inhibit the specific binding of [3H]-NMS to human M receptors in a dose-denpendent fasion with Ki values of 0.10±0.00nM,0.14±0.04nM, 0.14±0.02nM, 0.21±0.04nM and 0.16±0.01nM for M1, M2,M3,M4 and M5, respectively. In addition, Aclidinium Bromide has shown the great potency at endogenous M2 and M3 receptors with EC50 values of 17.4±1.1nM and 5.3±1.6nM, respectively. Apart from these, Aclidinium Bromide has been revealed to produce a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction in vivo with an EC50 of ranging from 2.5 to 23.1μg/mL in anaesthetized guines pigs. Besides, Aclidinium Bromide has also been noted to inhibit the salivation in rat pilocarpine-induced sialorrhea model with an EC50 of 38μg/kg [1].

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