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抑制剂 > 膜转运蛋白/离子通道 > Resolvin D2
产品名称:
Resolvin D2
型号:
CS-01Y75391
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

10μg 25μg 50μg 100μg

CAS

810668-37-2

别名

7(S),16(R),17(S)-Resolvin D2

化学名

7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid

分子式

C22H32O5

分子量

376.5

溶解度

50 mg/ml in DMF, 50 mg/ml Ethanol

储存条件

Store at -80°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid .[1]  In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. [2] Resolvin D2 (RvD2) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation. [3] It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM. Also, by stimulating nitric oxide production, RvD2 dose dependently decreases leukocyte-endothelial interactions. In a mouse model of sepsis, RvD2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance. Analytical and biological comparisons of synthetic RvD2 with endogenously derived RvD2 have confirmed its identity as matching the natural product. [4]

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Resolvin D2 

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