化学性质:
规格 | 5mg 10mg 50mg |
CAS | 552309-42-9 |
别名 | N/A |
化学名 | 2-((5-ethyl-6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide |
分子式 | C19H20N4O3S2 |
分子量 | 416.52 |
溶解度 | 5mg/ml in DMSO; 10mg/ml in DMF |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Transmembrane protein 16A (TMEM16A, also known as anoctamin-1) is a calcium-activated chloride channel (CaCC) with roles in transepithelial anion transport and smooth muscle contraction. T16A(inh)-A01 is an aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 μM.[1],[2] Its inhibitory effects are independent of voltage and do not prolong the rate of TMEM16A current deactivation.[2]T16A(inh)-A01 blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels.[3] It also inhibits the proliferation of pancreatic cancer and squamous carcinoma cells in culture.[4],[5]
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