化学性质:
规格 | 1 mg 5 mg 10 mg 25 mg 50 mg |
CAS | 1392826-25-3 |
别名 | N/A |
化学名 | N/A |
分子式 | C19H21D6NO3 |
分子量 | 323.5 |
溶解度 | DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Tetrabenazine-d6 is intended for use as an internal standard for the quantification of tetrabenazine by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay). It dose-dependently reduces levels of the monoamines norepinephrine , dopamine , and serotonin in rat brain and has been used to induce depressive-like behavior in animal models. Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease. Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease.
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