PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine)CS-01Y75339

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一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg
CAS	55476-47-6
别名	N/A
化学名	N/A
分子式	C19H15NO3S
分子量	337.39
溶解度	DMSO : 25 mg/mL (74.10 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4.

PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM)[1].

[1]. Hernandez-Olmos V, et al. N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9576-88. [2]. Stokes L, et al. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Front Pharmacol. 2017 May 23;8:291.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine)

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