化学性质:
规格 | 5mg 10mg 50mg 200mg |
CAS | 101 |
别名 | S 0859;S-0859 |
化学名 | 2-chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide |
分子式 | C29H24ClN3O3S |
分子量 | 530.04 |
溶解度 | DMF: 50 mg/mL,DMSO: 30 mg/mL,Ethanol: 50 mg/mL,PBS (pH 7.2): 10 mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
S0859 is a selective, high-affinity generic NBC inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues[1].
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