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Tetraethylammonium chloride (TEAC) is a quaternary ammonium compound, which has been used as the source of tetraethylammonium ions in pharmacological and physiological studies.

In vitro: Tetraethylammonium (TEA) is a small ion that is thought to block open K channels by binding either to an internal or to an external site. For this reason, it has been used to probe the ion conduction pathway or pore of K channel mutants and a K channel chimera. TEA blocks K+ channels at two sites, which define the inner and outer mouths of the channel pores [1].

In vivo: Vasorelaxant effect of taurine can be diminished by TEA in rat isolated arteries [2]

Clinical trial: TEAC blocks both sympathetic and parasympathetic transmission at the ganglia. TEAC can relieve the pain of coronary artery disease. By the use of TEAC, the symptoms of Buerger's disease seem to be meliorated, at least temporarily. TEAC appears to be of little value in advanced arteriosclerotic diseases [3].

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