上海莼试生物技术有限公司
热卖产品最新促销最新推荐
抑制剂 > 其它信号转导 > Myr-ZIP
产品名称:
Myr-ZIP
型号:
CS-01Y74974
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 mg 5 mg 10 mg

CAS

N/A

别名

N/A

化学名

N/A

分子式

C90H154N30O17·XCF3COOH

分子量

1928.4

溶解度

Water: 1 mg/ml

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Myr-ZIP is a cell-permeable inhibitor of the constitutively active protein kinase C (PKC) isoform PKMζ (Ki = 0.076-2.11 µM).1,2 It also inhibits PKCα when used at a concentration of 10 µM.3 Myr-ZIP (5 µM) prevents PKC translocation to the plasma membrane induced by ionomycin in HEK293 cells expressing A-kinase anchor protein 79 (AKAP79). Myr-ZIP inhibits the conditioned place preference response to morphine in rats when administered intracranially into the nucleus accumbens core at doses of 10 and 30 nmol/0.5 µl per side.4

1.Yao, Y., Shao, C., Jothianandan, D., et al.Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neuronsNeuropharmacology64(1)37-44(2013) 2.Lee, A.M., Kanter, B.R., Wang, D., et al.Prkcz null mice show normal learning and memoryNature493(7432)419-419(2013) 3.Bogard, A.S., and Tavalin, S.J.Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocationMol. Pharmacol.88(4)728-735(2015) 4.Li, Y.-q., Xue, Y.-x., He, Y.-y., et al.Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memoryJ. Neurosci.31(14)5436-5446(2011)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Myr-ZIP 

联系我们

联系人:高小姐

手    机:13585831301

Q      Q:3004967995

座    机:021-59541103

传    真:021-60443211

地    址:上海市嘉定区澄浏公路52号中科院技术转移中心24号楼