化学性质:
规格 | 5mg 10mg 25mg |
CAS | 484-42-4 |
别名 | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu |
化学名 | Angiotensin I (human, mouse, rat) |
分子式 | C62H89N17O14 |
分子量 | 1296.5 |
溶解度 | ≥ 129.6mg/mL in DMSO, ≥ 124.2 mg/mL in H2O |
储存条件 | Desiccate at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Angiotensin I (Ang I) (C62H89N17O14), with the sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH, is formed by the action of renin on angiotensinogen. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure (<90mmHg systolic blood pressure) at the juxtaglomerular cells. Ang I appears to have no biological activity and exists solely as a precursor to angiotensin II (A II). Ang I is cleaved to Ang II by the angiotensin-converting enzyme (ACE). Ang II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates contraction by an IP3-dependent mechanism).
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标签:Angiotensin I (human mouse rat)
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