Pancuronium (bromide hydrate)CS-01Y74882_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5 mg 10 mg 25 mg
CAS	N/A
别名	N/A
化学名	N/A
分子式	C35H60N2O4.2Br [XH2O]
分子量	732.7
溶解度	DMF: 5 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC50 value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs.1 It acts as a non-depolarizing neuromuscular blocking agent.2 Pancuronium enhances anesthesia induced by isoflurane , reducing immobilization with an ED50 value of 1.62 µg/kg.3

1.Liu, M., and Dilger, J.P.Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptorMol. Pharmacol.75(1)166-173(2009) 2.Buckett, W.R., Marjoribanks, C.E., Marwick, F.A., et al.The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agentBr. J. Pharmacol. Chemother.32(3)671-682(1968) 3.Miyazaki, Y., Sunaga, H., Hobo, S., et al.Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptorsJ. Anesth.30(4)671-676(2016)

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标签：Pancuronium (bromide hydrate)

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抑制剂 > 膜转运蛋白/离子通道 > Pancuronium (bromide hydrate)

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