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(±)-Indoxacarb is a broad-spectrum oxadiazine insecticide.1 It is metabolized in vivo to its active N-decarbomethoxyllated metabolite DCJW. Topical administration of (±)-indoxacarb is lethal to S. frugiperda, H. virescens, L. lineolaris, N. cincticeps, N. lugens, L. decemlineata, A. grandis, and M. domestica (LD50s = 0.03, 0.44, 1.6, 0.72, >7.8, 2.81, 6.45, and 15 ng/mg, respectively). It suppresses voltage-gated sodium channel currents in rat dorsal root ganglion neurons in a concentration-dependent manner.2 Formulations containing (±)-indoxacarb have been used to control various insect pests in tea farming.3

|1. Wing, K.D., Sacher, M., Kagaya, Y., et al. Bioactivation and mode of action of the oxadiazine indoxacarb in insects. Crop Prot. 19(8-10), 537-545 (2000).|2. Nagata, K., Ikeda, T., Honda, H., et al. Suppression of voltage-gated sodium currents by the dihydropyrazole insecticide, DPX-JW062 in rat dorsal root ganglion neurons. J. Pesticide Sci. 23(1), 62-64 (1998).|3. Zhang, X., Luo, F., Lou, Z., et al. Simultaneous and enantioselective determination of cis-epoxiconazole and indoxacarb residues in various teas, tea infusion and soil samples by chiral high performance liquid chromatography coupled with tandem quadrupole-time-of-flight mass spectrometry. J. Chromatogr. A 1359, 212-223 (2014).

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