上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 500 µg |
| CAS | 119340-53-3 |
| 别名 | N/A |
| 化学名 | N/A |
| 分子式 | C15H21N5O13P2 |
| 分子量 | 541.3 |
| 溶解度 | N/A |
| 储存条件 | -80°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3].
cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5].
cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].
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标签：Cyclic ADP-ribose
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