化学性质：                                                                                                             

产品描述：                                                                                                            

3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) is an ATP-sensitive potassium channel activator, can be used to treat hyperinsulinism.

3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia[1].

3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage[2].

3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels[3]. Treatment with 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg[4].

特别提醒：