化学性质:
规格 | 1mg 5mg 10mg |
CAS | 57186-25-1 |
别名 | N/A |
化学名 | (2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one |
分子式 | C27H33NO4 |
分子量 | 435.56 |
溶解度 | 10mg/mL in ethanol, 30mg/mL in DMSO, or in DMF |
储存条件 | Desiccate at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).[1],[2]It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels.[3] Paxilline is currently used to evaluate the role of BKCa channels in various cell processes and responses.[4],[5]
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标签:Paxilline
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