化学性质:
规格 | 500μg 1mg 5mg |
CAS | 1 |
别名 | N/A |
化学名 | N/A |
分子式 | C15H14N2O3 |
分子量 | 270.3 |
溶解度 | DMF: 1 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Compound C108 is an inhibitor of the GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2), which is involved in breast tumor initiation. In a mouse xenograft model of breast cancer, compound C108 (1 µM for 24 hours) reduces the proportion of tumor-initiating cells approximately 10-fold compared with untreated cells. In MDA-MB-453 cells, and in the patient-derived xenograft cell line MAXF 401, it diminishes mammosphere formation.
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