上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 10mg 25mg 50mg |
| CAS | 545395-94-6 |
| 别名 |
|
| 化学名 | (Z)-3-(4-(tert-butyl)phenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide |
| 分子式 | C21H23NO3 |
| 分子量 | 337.42 |
| 溶解度 | ≥ 33.7mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
AMG 9810 is a vanilloid receptor 1 (VR1 or TRPV1) antagonist, with IC50 values for human TRPV1 of 24.5±15.7 nM, for rat TRPV1 of 85.6 ±39.4 nM as a competitive antagonist of capsaicin activation. To block protons, its IC50 values for rat TRPV1 is 294±192 nM, for human TRPV1 is 92.7±72.8 nM. To block heat, its IC50 value for rat TRPV1 is 21±17 nM, for human TRPV1 is 15.8±10.8 nM. It can also block endogenous ligands, such as N-arachidonyl dopamine, anandamide and oleoyldopamine [1].
TRPV1 is expressed by peripheral sensory neurons. It is a membrane-bound, nonselective cation channel [1].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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