化学性质:
规格 | 10 mg 50 mg |
CAS | 351424-20-9 |
别名 | N/A |
化学名 | N/A |
分子式 | C15H11Cl2NO4 |
分子量 | 340.16 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.
Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID:29996905 |Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID:29579323
特别提醒:
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2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:CBA
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