化学性质:
规格 | 10mM (in 1mL DMSO) 5mg 25mg 100mg |
CAS | 118292-40-3 |
别名 | N/A |
化学名 | ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate |
分子式 | C21H21NO2S |
分子量 | 351.46 |
溶解度 | ≥ 14.85mg/mL in DMSO, ≥ 11.1 mg/mL in EtOH with ultrasonic |
储存条件 | Store at 2-8°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Tazarotene, one of the acetylenic class of retinoids, is the 3rd-generation prescription topical retinoid. It is approved for treating psoriasis, acne, and photo damaged skin [1].
Tazarotene act as a retinoid prodrug and it is converted to free acid form by rapid deesterification when used in man and animals. Tazarotenic acid shows selectivity for (RAR)-β, and (RAR)-γ though it could bind to all three classes of the retinoic acid receptor (RAR) family, and this may modify gene expression.
Tazarotene mediates these effects by regulating gene transcription. Five nonsmall cell lung carcinoma (NSCLC) cell lines and the constitutive and all-trans retinoic acid (ATRA)-inducible expression of tazarotene-induced gene3 mRNA of the five head and neck squamous cell carcinoma (HNSCC) were examined to determine whether it is associated with their responsiveness to ATRA. Consequently, ATRA induced tazarotene-induced gene3 mRNA from 6 to 12h in most of the responsive cells. Depending on the cell line, the concentration of ATRA required for induction of tazarotene-induced gene3 was ranged from 1 to 500 nm [2].
67 patients aging from 13 to 30 with facial acne attended a study to evaluate the safety and efficacy of topical tazarotene 0.1% cream in the treatment of facial acne. Patients were instructed to apply topical tazarotene cream (0.1%) as a thin film over the affected part in the evening once a day for 12 weeks. And follow-ups were done at 2nd, 4th, 8th and 12th week. As a result, 53% of the patients got remission, 9% had good response, 34% had poor response and 4% of the patients by 12 weeks of treatment was no response. Topical tazarotene cream (0.1%) is an effective and safe treatment method for the face affected by acne vulgaris [3].
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:Tazarotene
联系人:高小姐
手 机:13585831301
Q Q:3004967995
座 机:021-59541103
传 真:021-60443211
地 址:上海嘉定区嘉罗公路1661