Sitagliptin phosphate monohydrateCS-01Y73950_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5 mg 10 mg 25 mg 50 mg 100 mg
CAS	1253226-93-5
别名	N/A
化学名	N/A
分子式	C24H24Cl2N2O2
分子量	443.37
溶解度	DMSO : 41.67 mg/mL (93.98 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively[1].

AS1708727 suppresses increases in blood glucose level by inhibiting gluconeogenic gene expression[1].

AS1708727 (30 to 300 mg/kg, orally) reduces both blood glucose and triglyceride levels, exhibiting anti-diabetic effects[1].

[1]. Hirotsugu Tanaka, et al. Effects of the Novel Foxo1 Inhibitor AS1708727 on Plasma Glucose and Triglyceride Levels in Diabetic Db/Db Mice. Eur J Pharmacol. 2010 Oct 25;645(1-3):185-91.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：AS1708727

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抑制剂 > 泛素化/蛋白酶体 > Sitagliptin phosphate monohydrate

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