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抑制剂 > 泛素化/蛋白酶体 > Spermidine-d6
产品名称:
Spermidine-d6
型号:
CS-01Y73948
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 mg 5 mg

CAS

2514812-10-1

别名

N/A

化学名

N/A

分子式

C7H13D6N3

分子量

151.3

溶解度

Water: 50 mg/ml

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine.1 It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay.1 It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans.2 Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).3 It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.

1.Madeo, F., Eisenberg, T., Pietrocola, F., et al.Spermidine in health and diseaseScience359(6374)eaan2788(2018) 2.Eisenberg, T., Knauer, H., Schauer, A., et al.Induction of autophagy by spermidine promotes longevityNat. Cell Biol.11(11)1305-1314(2009) 3.Guo, X., Harada, C., Namekata, K., et al.Spermidine alleviates severity of murine experimental autoimmune encephalomyelitisInvest. Ophthalmol. Vis. Sci.52(5)2696-2703(2011) 4.Eisenberg, T., Abdellatif, M., Schroeder, S., et al.Cardioprotection and lifespan extension by the natural polyamine spermidineNat. Med.22(12)1428-1438(2016)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Spermidine-d6 

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