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Corosolic acid has high inhibitory activity against α-glucosidase with an IC50 of 3.53 μg/mL [1].

Corosolic acid (CRA) is an extract of banana leaves. It has been reported that corosolic acid had many beneficial effects like decreasing blood sugar level, antihyperlipidemic, antiviral, anti-inflammatory, and antifungal activities [2].

When tested with Chinese hamster ovary cell, treated with corocolic acid showed high hypoglycemic effects via stimulating glucose uptake and inhibiting several diabetes-related nonreceptor protein tyrosine phosphatase enzymes [3].

In mouse model with genetically diabetic disease, feeding the mice with banana leaf extraction (containing highly purified corosolic) significantly suppressed the blood glucose level [4]. When tested with SHR/NDmcr-cp (cp/cp) rat (animal model of metabolic syndrome), compared with control group, rats were fed a high fat diet containing 0.072% corosolic acid for 14 weeks decreased the blood pressured with significant difference[5]

In a human clinical study, type 2 diabetic subjects were given daily 0.32 and 0.48 mg corosolic acid respectively for 2 weeks and a 30% decreasement of blood glucose level was observed [6].

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