化学性质:
规格 | 10mg |
CAS | 57265-65-3 |
别名 | R 24571 |
化学名 | (S)-1-(bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride |
分子式 | C31H23Cl7N2O |
分子量 | 687.7 |
溶解度 | 100mM in ethanol, or in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 μM, respectively).[1] Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 μM, respectively).[1] It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 μM).[2],[3]
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