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Myrothecine A is a trichothecene mycotoxin that has been found in M. roridum and has anticancer activities.1,2 It inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (IC50s = 95, 70, 60, and 25 μM, respectively).1 Myrothecine A (50 μM) induces G1 cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells.1,2

|1. Lin, T., Wang, G., Zhou, Y., et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J. Agric. Food Chem. 62(25), 5993-6000 (2014).|2. Song, H., Fu, Y., Wan, D., et al. Mytoxin B and myrothecine A induce apoptosis in human hepatocarcinoma cell line SMMC-7721 via PI3K/Akt signaling pathway. Molecules 24(12), E2291 (2019).

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