化学性质:
规格 | 1 mg 5 mg 10 mg |
CAS | 138768-62-4 |
别名 | N/A |
化学名 | N/A |
分子式 | C15H24N2O4 |
分子量 | 296.4 |
溶解度 | Acetonitrile: 10 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
N-Nitroso metoprolol is a genotoxic derivative of metoprolol .1,2 It induces DNA fragmentation in rat hepatocytes when used at concentrations ranging from 0.1 to 1 mM.1 In vivo, N-nitroso metoprolol (1,000 mg/kg) induces micronucleation of rat hepatocytes but not erythrocytes from the bone marrow or spleen.
1.Robbiano, L., Martelli, A., Allavena, A., et al.Formation of the N-nitroso derivatives of six β-adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytesCancer Res.51(9)2273-2279(1991) 2.Martelli, A., Allavena, A., Sottofattori, E., et al.Low clastogenic activity in vivo of the N-nitroso derivatives of 5 β-adrenergic-blocking drugs proved to be potent genotoxins in vitroToxicol. Lett.73(3)185-191(1994).
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