Pyridostatin (trifluoroacetate salt)CS-01Y73740_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1 mg 5 mg 10 mg 25 mg
CAS	1472611-44-1
别名	N/A
化学名	N/A
分子式	C31H32N8O5.C2HF3O2
分子量	710.7
溶解度	DMF: 30 mg/mL,DMSO: 20 mg/mL,Ethanol: 5 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.1

1.Rodriguez, R., Miller, K.M., Forment, J.V., et al.Small-molecule-induced DNA damage identifies alternative DNA structures in human genesNat. Chem. Biol.8(3)301-310(2012)

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1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Pyridostatin (trifluoroacetate salt)

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