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Cacodylic acid has been widely used in buffers for electron microscopy techniques.1 It has also been used to introduce arsenic into proteins for single-wavelength anomalous diffraction (SAD) phasing in protein crystallography.2 Cacodylic acid has also been used as an herbicide, acting as a defoliant.3 In rats exposed to carcinogens, cacodylic acid increases the likelihood of tumor formation in the bladder, kidney, liver, and thyroid gland at concentrations as low as 50 ppm for the bladder.4

1.Graham, L., and Orenstein, J.M.Processing tissue and cells for transmission electron microscopy in diagnostic pathology and researchNat. Protoc.2(10)2439-2450(2007) 2.Liu, X., Zhang, H., Wang, X.J., et al.Get phases from arsenic anomalous scattering: De novo SAD phasing of two protein structures crystallized in cacodylate bufferPLoS One6(9)1-8(2011) 3.Mastradone, P.J., and Woolson, E.A.Levels of arsenical species in cotton after field application of a cacodylic acid defoliantBull. Environ. Contam. Toxicol.31(2)216-221(1983) 4.Yamamoto, S., Konishi, Y., Matsuda, T., et al.Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogensCancer Res.55(6)1271-1276(1995)

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