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Acetyl hexapeptide-3 is a synthetic acetylated and amidated hexapeptide consisting of amino acid residues 12-17 of synaptosomal-associated protein 25 (SNAP-25).1 It inhibits formation of the SNARE complex in vitro in a concentration-dependent manner. It also inhibits calcium-induced norepinephrine release in permeabilized chromaffin cells (IC50 = 110 μM). Acetyl hexapeptide-3 (10% in an oil-and-water emulsion) inhibits decreases in type I collagen levels and skin thickness, as well as increases in type III collagen levels, in skin in a mouse model of subacute aging induced by D-galactose when administered topically.2

1.Blanes-Mira, C., Clemente, J., Jodas, G., et al.A synthetic hexapeptide (argireline) with antiwrinkle activityInt. J. Cosmet. Sci.24(5)303-310(2002) 2.Wang, Y., Wang, M., Xiao, X.S., et al.The anti-wrinkle efficacy of argirelineJ. Cosmet Laser Ther.15(4)237-241(2013)

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