Y-39983 dihydrochlorideCS-01Y73640_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	2mg 5mg 10mg 50mg 100mg
CAS	173897-44-4
别名	N/A
化学名	4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;dihydrochloride
分子式	C16H18Cl2N4O
分子量	353.25
溶解度	DMSO : 100 mg/mL (283.09 mM); H2O : 50 mg/mL (141.54 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Y-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK [1].

Y-39983 dihydrochloride has shown a selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6nM, 0.42μM and 0.81μM for ROCK, PKC and CaMKII, respectively [1]. Apart from these, Y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. In addition, Y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. Moreover, Y-39983 lowered the intraocular pressure ( IOP) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].

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标签：Y-39983 dihydrochloride

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