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Metacetamol is a derivative of acetaminophen .1,2,3 Unlike acetaminophen, metacetamol is not cytotoxic to isolated mouse hepatocytes (LC50 = >10 mM).1 However, it does induce necrosis and depletion of glutathione (GSH) in isolated human hepatocytes when used at a concentration of 10 mM.2 Metacetamol (900 mg/kg) does not induce hepatic necrosis in mice.3

1.Holme, J.A., Hongslo, J.K., BjØrge, C., et al.Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytesBiochem. Pharmacol.42(5)1137-1142(1991) 2.Xie, Y., McGill, M.R., Du, K., et al.Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytesToxicol. Appl. Pharmacol.289(2)213-222(2015) 3.Nelson, E.B.The pharmacology and toxicology of meta-substituted acetanilide I: Acute toxicity of 3-hydroxyacetanilide in miceRes. Commun. Chem. Pathol. Pharmacol.28(3)447-456(1980)

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