上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | mM (in 1mL DMSO) 25mg 100mg |
| CAS | 118072-93-8 |
| 别名 |
|
| 化学名 | (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid |
| 分子式 | C5H10N2O7P2 |
| 分子量 | 272.09 |
| 溶解度 | ≥ 6.8mg/mL in H2O with gentle warming |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Zoledronic Acid induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
标签：Zoledronic Acid
联系人：高小姐
手 机：13585831301
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传 真：021-60443211
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