化学性质:
规格 | 10mg 25mg 50mg |
CAS | 3 |
别名 | N/A |
化学名 | 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione |
分子式 | C19H18N2O2 |
分子量 | 306.4 |
溶解度 | DMF: 12.5 mg/mL,DMSO: 20 mg/mL,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL,Ethanol: 0.25 mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). It blocks taxol-induced assembly of tubulin (IC50 = 6 uM) and blocks colchicine binding to tubulin. Like colchicine, TN-16 inhibits alkylation of tubulin. TN-16 induces metaphase arrest in renal cell carcinoma cells. TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.
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