CDK4 inhibitorCS-01Y73401_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mg 25mg 50mg 100mg
CAS	1256963-02-6
别名	N/A
化学名	4-(3-chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine
分子式	C22H29ClN8
分子量	440.97
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.25 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

CDK4 inhibitor is a selective inhibitor of cyclin-dependent kinase 4 with IC50 value of 10 nM [1].

Cyclin-dependent kinase 4 (CDK4) is a Ser/Thr protein kinase and is a member of the cyclin-dependent kinase family. CDK4 plays an important role in the G1-S phase.

CDK4 inhibitor is a selective cyclin-dependent kinase 4 inhibitor. CDK4 inhibitor inhibited CDK4/Cyclin D1, CDK1/Cyclin B and CDK2/Cyclin A with IC50 values of 10 nM, 15 μM and 5.265 μM, respectively. Also, it inhibited protein kinase A (PKA) and glycogen synthase kinase (GSK3β) with IC50 values of 6.8 and 9.6 μM, respectively. In a mantle-cell lymphoma cell line Jeko-1, CDK4 inhibitor inhibited the phosphorylation level of pRb at the Ser780 site with IC50 value of 0.324 μM. Also, CDK4 inhibitor (0.37 μM) showed G1 block on cells [1].

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标签：CDK4 inhibitor

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