化学性质:
规格 | 10 mg 50 mg 100 mg 250 mg |
CAS | 76168-82-6 |
别名 | N/A |
化学名 | N/A |
分子式 | C119H154ClN21O40 (for A2) |
分子量 | 2554.1 |
溶解度 | DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Ramoplanin complex is a mixture of ramoplanin A1, -A2, and -A3 originally isolated from Actinoplanes that has antibacterial activity.1,2,3 Ramoplanin complex is active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 μg/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 μg/ml).2 It inhibits cell wall synthesis in B. subtilis when used at a concentration of 0.5 μg/ml.1 Ramoplanin complex is effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice with ED50 values of 0.081, 0.14, and approximately 25 mg/kg per day, respectively.
1.Cavalleri, B., Pagani, H., Volpe, G., et al.A-16686, a new antibiotic from actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristicsJ. Antibiot. (Tokyo)37(4)309-317(1984) 2.Pallanza, R., Berti, M., Scotti, R., et al.A-16686, a new antibiotic from actinoplanes. II. Biological propertiesJ. Antibiot. (Tokyo)37(4)318-324(1984) 3.Shin, D., Rew, Y., and Boger, D.L.Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complexProc. Natl. Acad. Sci. USA101(33)11977-11979(2004)
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