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抑制剂 > 微生物学和病毒学 > Thimerosal
产品名称:
Thimerosal
型号:
CS-01Y73268
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

10g 25g 50g

CAS

54-64-8

别名

N/A

化学名

N/A

分子式

C9H9HgO2S Na

分子量

404.8

溶解度

Ethanol: soluble,Water: soluble

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Thimerosal is a mercurial antimicrobial agent.1,2 It is bacteriostatic against hemolytic streptococci and fungistatic against H. capsulatum, B. dermatitidis, and S. schenckii. Thimerosal (1-250 μM) induces apoptosis in HCN-1A human cortical neurons and various neuroblastoma cells.3,4 In vivo, thimerosal (80 mg/kg, i.p.) induces footpad swelling and dorsal skin contact dermatitis in a mouse model of pseudo-allergic reaction.5 Formulations containing thimerosal have been used as antiseptics and preservatives in vaccines.

1.Morton, H.E., North, L.L., Jr., and Engley, F.B., Jr.The bacteriostatic and bactericidal actions of some mercurial compounds on hemolytic streptococciJ. Am. Med. Assoc.136(1)37-41(1948) 2.Deighton, F.J., Hall, N.K., and Larsh, H.W.Merthiolate treatment of pathogenic fungiJ. Clin. Microbiol.10(2)144-146(1979) 3.Baskin, D.S., Ngo, H., and Didenko, V.V.Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblastsToxicol. Sci.74361-368(2003) 4.Dórea, J.G.Integrating experimental (in vitro and in vivo) neurotoxicity studies of low-dose thimerosal relevant to vaccinesNeurochem. Res.36(3)927-038(2011) 5.Peng, B., Che, D., Hao, Y., et al.Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2J. Dermatol. Sci.95(3)99-106(2019)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Thimerosal 

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