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Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties.1,2 It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 μg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 μg/ml, respectively).1 It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 μg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.2

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