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抑制剂 > 微生物学和病毒学 > Solanesol
产品名称:
Solanesol
型号:
CS-01Y73249
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 g 5 g 10 g 25 g

CAS

13190-97-1

别名

N/A

化学名

N/A

分子式

C45H74O

分子量

631.1

溶解度

Ethanol: 0.25mg/mL

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Solanesol is a trisesquiterpenoid that has been found in N. tabacum and has diverse biological activities.1,2,3 It is active against E. coli, M. phlei, P. aeruginosa, and S. aureus.1 Solanesol (40 μM) increases basal heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) activities and inhibits LPS-induced production of IL-6, IL-1β, and TNF-α in RAW 264.7 cells.2 It reduces escape latency in the Morris water maze and the number of slips in a beam-crossing task in a rat model of Huntington's disease induced by 3-nitropropionic acid when administered at doses of 5, 10, and 15 mg/kg.3 Solanesol is also a precursor in the formation of polynuclear aromatic hydrocarbons (PAHs), which are carcinogenic components of tobacco smoke, and has been used as a synthetic intermediate in the synthesis of coenzyme Q10 and vitamin K analogs that have antioxidant activities.1

1.Yan, N., Liu, Y., Liu, L., et al.Bioactivities and medicinal value of solanesol and its accumulation, extraction technology, and determination methodsBiomolecules9(8)334(2019) 2.Yao, X., Lu, B., Lü, C., et al.Solanesol induces the expression of heme oxygenase-1 via p38 and Akt and suppresses the production of proinflammatory cytokines in RAW264.7 cellsFood Funct.8(1)132-141(2017) 3.Mehan, S., Monga, V., Rani, M., et al.Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunctionIndian J. Pharmacol.50(6)309-319(2018)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Solanesol 

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