化学性质：                                                                                                             

产品描述：                                                                                                            

TunR2 is an antibiotic and derivative of tunicamycin .1 It is active against B. subtilis (MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G against B. subtilis when used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic to S. cerevisiae (MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared with tunicamycin.

1.Price, N.P., Hartman, T.M., Li, J., et al.Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactamsJ. Antibiot. (Tokyo)70(11)1070-1077(2017)

特别提醒：