化学性质:
规格 | 1 mg |
CAS | |
别名 | N/A |
化学名 | N/A |
分子式 | C22H26O8 |
分子量 | 418.4 |
溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities.1,2,3 It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 μM.1 Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 μg/ml).2 It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 μM).3
1.Thadhani, V.M., Choudhary, M.I., Ali, S., et al.Antioxidant activity of some lichen metabolitesNat. Prod. Res.25(19)1827-1837(2011) 2.Lai, D., Odimegwu, D.C., Esimone, C., et al.Phenolic compounds with in vitro activity against respiratory syncytial virus from the Nigerian lichen Ramalina farinaceaPlanta Med.79(15)1440-1446(2013) 3.Majmudar, C.Y., H jfeldt, J.W., Arevang, C.J., et al.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300Angew. Chem. Int. Ed. Engl.51(45)11258-11262(2012)
特别提醒:
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