STING agonist-1CS-01Y73070_上海莼试生物技术有限公司

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化学性质：

规格	5mg 10mg 50mg 100mg
CAS	702662-50-8
别名
化学名	(Z)-4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carbimidic acid
分子式	C21H16ClFN2O3S
分子量	430.88
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 0.5 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].

G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].G10 is an indirect activator of human STING-dependent phenotypes[1].G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].G10 induces innate antiviral mRNA expression in primary human cells[1].

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标签：STING agonist-1

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抑制剂 > 微生物学和病毒学 > STING agonist-1

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