Thonzonium BromideCS-01Y72984_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10 mM * 1 mL in DMSO 10mg 50mg
CAS	553-08-2
别名	N/A
化学名	N-(2-((4-methoxybenzyl)(pyrimidin-2-yl)amino)ethyl)-N,N-dimethylhexadecan-1-aminium bromide
分子式	C32H55BrN4O
分子量	591.71
溶解度	≥ 53.5 mg/mL in DMSO, ≥ 62.1 mg/mL in H2O, ≥ 121.2 mg/mL in EtOH
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Thonzonium Bromide is a surface active agent and an inhibitor of V-ATPase proton transport with EC50 value of 69 μM [1] [2].

Vacuolar ATPases (V-ATPases) are proton pumps that maintain pH homeostasis. V-ATPases couple the energy of ATP hydrolysis to proton transport across intracellular membranes [2].

Thonzonium Bromide is a surface active agent and an inhibitor of V-ATPase proton transport. In wild-type yeast cells, thonzonium bromide significantly decreased the cytosolic pH to 6.22. In vacuolar membrane vesicles, thonzonium bromide inhibited proton transport with EC50 value of 69 μM in a dose-dependent way. However, thonzonium bromide didn’t inhibit ATP hydrolysis, which suggested that thonzonium bromide uncoupled V-ATPase proton pumps. In wild-type yeast cells, thonzonium bromide (1 μM) didn’t inhibit cell growth. However, thonzonium bromide inhibited cell growth at 10 μM and caused a mild vma (vacuolar membrane ATPase) mutant growth phenotype. At concentrations up to 50 and 100 μM, thonzonium bromide completely inhibited yeast growth [2].

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