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Miconazole-d5 is intended for use as an internal standard for the quantification of miconazole by GC- or LC-MS. Miconazole is an imidazole antifungal.1 It is active against C. parapsilosis, C. pseudotropicalis, C. albicans, C. neoformans, C. tropicalis, and C. guilliermondii (MICs = <0.1-10 μg/ml). It is also active against various Trichophyton species, A. fumigatus, A. niger, B. brasiliensis, and B. dermatitidis. Miconazole (160 mg/kg) prevents infection with T. mentagrophytes and M. canis in mice. It also reduces lesion size in a guinea pig model of C. albicans infection. Formulations containing miconazole have been used in the treatment of various fungal infections.

1.Sawyer, P.R., Brogden, R.N., Pinder, R.M., et al.Miconazole: A review of its antifungal activity and therapeutic efficacyDrugs9(6)406-423(1975)

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