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Fluconazole-d4 is intended for use as an internal standard for the quantification of fluconazole by GC- or LC-MS. Fluconazole is a triazole antifungal agent that is effective against most Candida strains.1 In vivo, fluconazole at 0.5-100 mg/kg demonstrates protective activity in various experimental animal models of systemic fungal diseases including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, and histoplasmosis.2

1.Herbrecht, R., Nivoix, Y., Fohrer, C., et al.Management of systemic fungal infections: Alternatives to itraconazoleJ. Antimicrob. Chemother.56(Suppl 1)i39-i48(2005) 2.Saag, M.S., and Dismukes, W.E.Azole antifungal agents: Emphasis on new triazolesAntimicrobial Agents and Chemotherapy32(1)1-8(1988)

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