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Norwogonin is a polyhydroxy flavone that has been found in S. baicalensis and has diverse biological activities, including antioxidant, antiviral, and anticancer properties.1,2,3 It scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals with IC50 values of 1.24 and 35.61 μg/ml, respectively, in cell-free assays.1 Norwogonin inhibits cytopathic effects induced by enterovirus 71 (EV71) in infected Vero cells (IC50 = 31.83 μg/ml).2 It reduces the viability of MDA-MB-231, BT-549, HCC70, and HCC1806 triple-negative breast cancer (TNBC) cells (IC50s = 32.24, 56.2, 39.05, and 37.3 μM, respectively) but not the non-tumorigenic cell lines MCF-10A and AG11132 (IC50s = >100 μM for both).3 Norwogonin induces cell cycle arrest at the G1 and G2/M phases and increases apoptosis in MDA-MB-231 cells in a concentration-

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